project_code,administering_organisation,lead_investigator,grant_summary,current_funding_dollars,official_record_url,chart_label PFG002002,The University of Adelaide,Prof Peter Langridge,"Australian Centre for Plant Functional Genomics. The ACPFG is working to improve the resistance of wheat and barley to hostile environmental conditions, using functional genomics technologies. Scientists at the ACPFG are focusing on stresses that impact agriculture in Australia, including drought, salinity, high or low temperatures and mineral deficiencies or toxicities. These stresses, known as abiotic stresses, are a major cause of cereal crop yield and quality loss throughout the world.",10461544.0,https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/PFG002002,PFG002002 — The University of Adelaide DP0208295,The University of Queensland,Prof David Adams,"Conotoxins: Novel probes for ion channel structure and function. Voltage-dependent and ligand-gated ion channels are intrinsic membrane proteins that play a central role in communication in excitable cells, particularly in the nervous system. The primary goals of this project are (i) to define at a molecular level, the structural and functional determinants of ion channel/conotoxin interactions and (ii) develop new probes that advance neurophysiological research. The diversity and distribution of ion channel types and subtypes being uncovered through the use of molecular biology and conotoxin probes presents an exciting opportunity for the future development of novel ion channel therapeutics.",2514598.0,https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0208295,DP0208295 — The University of Queensland DP0208697,The University of Melbourne,Prof Geoffrey Taylor,"Frontier Experiments in High Energy Physics. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest. The ATLAS and Belle experiments probe two of the most significant questions in fundamental physics: what is the origin of mass, and why do we live in a universe composed of matter rather than antimatter? ",2105535.0,https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0208697,DP0208697 — The University of Melbourne DP0209211,The University of Western Australia,Prof Andrew Millar,"FUNCTIONAL GENOMICS OF PLANT MITOCHONDRIA: THEIR ROLE IN DEVELOPMENT, OXIDATIVE STRESS AND PLANT DEFENSE. Crops encounter many situations in their environment which place them under stress. Reactive oxygen molecules produced in these situations act as messengers to trigger defence mechanisms but also cause cellular damage. Mitochondria are the subcellular compartments involved in energy production and are essential for plant development and growth. However, they also have been implicated in the response of plants to stress and pathogen attack, and in production of reactive oxygen molecules. This proposal seeks to investigate how mitochondria are involved in these processes, using the latest plant genome information. Potential outcomes include crops better able to cope with environmental stress.",1929263.0,https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0209211,DP0209211 — The University of Western Australia DP0209466,The University of Queensland,Prof Peter Koopman,"MOLECULAR GENETICS OF MAMMALIAN SEXUAL DEVELOPMENT: Molecular roles of SRY and SOX9. The development of sexual characteristics is critical to the survival of almost all animal species. This project seeks to clarify how male and female embryos develop differently, focusing on the Y-chromosome maleness gene Sry, and a closely related and equally important gene Sox9. We will study how these genes are switched on in developing gonads and how they interact with other genes to bring about testis formation in male embryos. In this way we will discover new genes and mechanisms that are important for sexual identity and also other aspects of embryo development.",1877945.0,https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0209466,DP0209466 — The University of Queensland DP0208776,The University of Sydney,Em/Prof Maxwell Crossley,"Molecular Electronics: from electron transfer through photosynthesis towards functional nano devices. Molecular Electronics, the use of molecules to perform specific electronic functions, is a new and very rapidly expanded area of nanotechnology. We will elucidate basic principles of electrical conduction through single molecules, understand and mimic natural photosynthetic molecular electronic processes, and establish by synthesis of ""molecular wires"" and extension of current technology, new methods for probing nanoscale electron transfer. We will combine these aspects to develop applications in photovoltaic design and in the design of molecular-level circuitry. Possible long-term applications range from solar energy conversion to molecular recognition and sensing to new types of electronic processing akin to quantum computing.",1639794.0,https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0208776,DP0208776 — The University of Sydney LE0228799,The University of Sydney,Dr James Robertson,"Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to construct and operate two 8-metre optical/infrared telescopes, one in Chile, and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways not previously possible. Through membership of Gemini, Australian astronomers have access to the world-class facilities necessary to maintain their high international profile and great public visibility in Galactic and extragalactic astronomy, and also to enhance the national capacity to construct advanced scientific instrumentation. Australia has already won a contract to build one of the instruments.",1637051.0,https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LE0228799,LE0228799 — The University of Sydney FF0344414,The University of Sydney,Prof Catherine Stampfl,"Application of First-principles Theory in Condensed Matter Physics, Surface Physics, Chemistry, and Engineering: Coatings, Catalysis, and Devices. The project addresses areas of high technological interest, namely the development of nitride-based materials for hard-coatings, spintronic (control and use of electron spin) and optoelectronic (in the blue/UV energy range) devices - as well as the area of heterogeneous oxidation catalysis. Using state-of-the-art methods it will lead to the development of new materials and devices of relevance to industry.",1593454.0,https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FF0344414,FF0344414 — The University of Sydney DP0209507,James Cook University,Prof Terence Hughes,"Biodiversity of coral reefs. An international team will provide the first robust measures of the biodiversity, abundance and functional roles of key coral reef species at a global scale. We will examine the processes underlying biodiversity patterns through a multi-disciplinary program of research, which focusses on ecological and evolutionary mechanisms at multiple scales. A modelling component will provide the mechanistic link between large-scale patterns and multi-scale processes. This research is highly relevant for conservation and management of reef resources across international boundaries.",1574762.0,https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0209507,DP0209507 — James Cook University DP0210598,The University of Queensland,Prof David Fairlie,"Macrocyclic Peptidomimetics. Proteins and peptides are among the most exquisite examples of hosts/guests for molecular recognition. Composed of amino acid building blocks, peptides are highly flexible and structurally promiscuous, switching between multiple structures (random/strand/sheet/turn/helical) in solution. Peptides pay a significant entropy penalty to organize into the one structure recognised by a biological receptor and responsible for activity. We are developing new macrocycles, composed of molecular constraints and amino acids, organized into specific strand, turn, or helical shapes. These building blocks are more structured, more chemically stable, and have higher receptor affinities than peptides enabling potential uses as new biological tools, drug leads, catalysts, devices or new materials.",1568721.0,https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0210598,DP0210598 — The University of Queensland